Rejuve Anti Aging Medical Spa in Rancho Santa Margarita

STEM CELL JOINT INJECTIONS

KNEE PAIN

STEM CELL JOINT INJECTIONS

KNEE PAIN

Regenerative medicine treatments may offer a superior alternative to knee surgery or knee replacement.

Rediscover youthful mobility with Rejuve Anti Aging’s cutting-edge regenerative therapies. Our advanced trifecta joint injections—featuring PRP, Stem Cells, and Exosomes—provide a sophisticated, non-surgical solution for knee pain and joint injuries.

By harnessing your body’s innate healing power, these innovative treatments stimulate natural tissue repair and regeneration, effectively addressing common issues such as arthritis, meniscus tears, ligament injuries, and ACL damage. Unlike traditional approaches that only mask pain, our regenerative solutions target the root cause, promoting long-term healing and improved function.

Whether you’re an athlete looking to stay active, someone struggling with chronic knee discomfort, or simply seeking to maintain peak mobility as you age, Rejuve’s regenerative therapies can help you regain strength and flexibility. Experience a revitalized, pain-free life and potentially delay—or even avoid—costly and invasive surgery.

Skip the trauma and lengthy recovery of traditional knee surgery. Rejuve Anti Aging offers ultrasound guided stem cell Injections, a precise, image-guided approach using your Mesenchymal Stem Cells to repair damaged knee tissues. This innovative method promotes natural healing and improved function, avoiding the risks and drawbacks associated with conventional surgical interventions.

ACL Tears - Knee Osteoarthritis - Meniscus Tears

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PROVEN RESULTS

Stem cell therapy: clinically proven to reduce joint pain and improve mobility.

NATURAL & SAFE

Leveraging the body’s own processes combined with PRP, Stem Cells and Exosomes

SIMPLE 30 MIN PROCEDURE

Ultrasound guided, highly accurate joint injections without anesthesia or downtime.

100% GUARANTEE OF KNEE PAIN REDUCTION!

Details Available During The Consultation

Clinical Studies of Stem Cells and Knee Injuries​

Over the past decade, there has been a significant rise in research and publications on the therapeutic application of mesenchymal stem cells (MSCs) for knee injuries and conditions. This growing body of work highlights the strong interest and ongoing efforts to refine and optimize this cutting-edge treatment approach.

Recent studies have increasingly focused on uncovering the precise mechanisms of MSCs, moving beyond their differentiation potential to explore their crucial roles in paracrine signaling and immunomodulation. This deeper understanding has led to more targeted and effective applications in regenerative medicine.

The growing number of clinical trials investigating MSC therapy for various knee conditions reflects a dedicated push to translate promising preclinical findings into real-world benefits for patients suffering from chronic pain, ligament injuries, meniscus damage, and joint degeneration.

"Postpone the progress of knee OA and facilitate cartilage repair induced by MSC injection"

Intl Journal of Molecular Sciences

Knee Osteoarthritis: Mechanisms and Clinical Evidence

"Injection of MSCs significantly improved function and pain of the knee joint"

Journal of Stem Cells

The size of cartilage defect decreased while the volume of cartilage increased

"Mesenchymal stem cells demonstrated a clinically relevant improvement in outcomes"

American Journal of Sports Medicine

A comprehensive review of seventeen studies encompassing 367 patients

End Knee Pain!

Have you been told that the only way to relieve your knee pain is through steroid injections or invasive surgery?

Studies indicate that common knee surgeries, such as meniscectomies, frequently offer no greater benefit than placebo treatments. This raises concerns about their actual effectiveness in relieving pain and improving function.

While knee replacements remain necessary in some cases, they are highly invasive procedures with significant risks. The extensive rehabilitation required and the potential for accelerated joint degeneration, which can worsen long-term issues, call into question the overall appropriateness of these surgeries, particularly when considering available alternative treatments.

Stem Cell Therapy Could Be The Exact Non-Surgical Alternative You’ve Been Waiting For!

Reclaim your active lifestyle. Rejuve Anti-Aging offers non-surgical solutions to get you back to the activities you love.

The fear is real: a sudden, sharp pain, your knee buckling, a fall. The uncertainty of every step keeps you on edge, forcing you to second-guess simple movements. Imagine missing out on life’s most precious moments—watching from the sidelines instead of playing with your grandchildren, hesitating to take your dog for a walk, or declining invitations for fear your knee might give way.

For months, the locking, instability, and discomfort have held you back, making even routine activities feel risky. The thought of invasive surgery looms over you, with its long recovery times and uncertain outcomes. But what if there was another way?

At Rejuve Anti Aging, we understand the frustration and fear that come with knee pain and instability. That’s why we offer cutting-edge, non-surgical regenerative solutions designed to support your body’s natural healing process. With advanced treatments like PRP, Stem Cells, and Exosomes, we help you regain confidence, stability, and mobility—so you can reclaim your active lifestyle without the fear of surgery. Let us guide you toward a future of movement, strength, and freedom.

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Outcomes For Stem Cell Knee Procedures

Function Regained
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Decrease In Pain 1 Month
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Overall Improvement 3 Months
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COMMON KNEE CONDITIONS TREATED WITH STEM CELL JOINT INJECTIONS AT REJUVE ANTI AGING

  • Knee Osteoarthritis (OA)​

    Research increasingly indicates that common knee surgeries often fail to deliver positive outcomes, particularly for patients over 40. Even in younger individuals, success is not assured. Many people are unaware of these findings, highlighting a widespread misconception that surgery is a guaranteed solution.

    Knee osteoarthritis (OA) is a widespread orthopedic issue. If you're living with OA, you're familiar with the debilitating pain and discomfort that can significantly diminish your quality of life and enjoyment of everyday activities.

    At Rejuve, we utilize advanced mesenchymal stem cells (MSC) and exosome therapies, precisely delivered via ultrasound-guided injections. This minimally invasive approach stimulates your body's natural healing processes, offering a powerful alternative to traditional knee surgery.

  • ACL Tear Repair Without Surgery​

    When considering your knee health, it's crucial to weigh factors like recovery time, return to activity, and long-term well-being. At Rejuve Anti Aging, our goal is to preserve your natural ACL, not replace it. Current research and our extensive expertise indicate that natural healing of ACL injuries is often achievable.

    Our ACLR procedure involves a precise, ultrasound guided injection of mesenchymal stem cells and exosomes. This minimally invasive approach offers a significantly shorter recovery compared to traditional surgery.

    FeatureACLR (Rejuve Anti Aging)Surgery
    Procedure InvasivenessMuch lessMuch more
    Return to Sports3 to 6 months1 year
    Keep Your ACLYesNo
    RecoveryBrace, less extensive PTCrutches, brace, extensive PT
  • Meniscus Tear Recovery Time Without Surgery

    Traditional knee surgeries often necessitate a prolonged and demanding recovery. Patients typically face months of rehabilitation, frequently accompanied by substantial pain, to restore strength and function. While the precise recovery timeline varies depending on the injury, procedure, and individual health, it can extend up to six months. In contrast, Rejuve Anti Aging procedures, employing advanced regenerative therapies, aim to mitigate the drawbacks of surgery by promoting natural healing within the knee.

    This approach generally leads to a significantly abbreviated recovery, enabling patients to resume daily activities within weeks and return to more strenuous activities within a few months. Compared to traditional surgery's extensive bracing, prolonged physical therapy, and reliance on prescription pain medication, Rejuve Anti Aging typically involves minimal bracing, shorter physical therapy durations, and over-the-counter pain management.

    Furthermore, Rejuve Anti Aging focuses on preserving and revitalizing the knee's natural structures, unlike surgical removal.

    FeatureRejuve Anti AgingSurgery
    Return to Daily Routine2 to 5 days6+ weeks
    Return to Sports3 to 6 months1 year
    RecoveryBrace, up to 6 weeks, PTCrutches, brace, extensive PT, no driving, 3 to 6 months PT
    Pain ManagementMostly over-the-counter pain medication (days)Prescription pain medication for weeks (weeks)
    General AnesthesiaNoYes
    Preserve Natural Knee StructuresYesNo

KNEE JOINT HEALTH

The human body is designed to heal itself. Your body’s natural goal is repair and regeneration. A simple example is when you get a cut—your body stops the bleeding, forms a scab, and sends healing cells to close the wound.

This self-healing ability is constantly at work, even when you can’t see it. Your body is always scanning for damage and sending repair cells where they’re needed. However, certain factors influence how effectively your body can heal, including:

  • Smoking habits
  • Alcohol consumption
  • Sleep quality and duration
  • Regular physical activity
  • Nutrition and digestion
  • Stress management

Even with a healthy lifestyle—eating well, exercising, and getting enough rest—there are times when your body needs extra support. That’s where regenerative therapies at Rejuve Anti Aging can help. Our advanced treatments, including stem cell therapy and PRF, work with your body’s natural healing processes to restore function, reduce pain, and promote long-term wellness.

AND THAT’S WHERE REJUVE ANTI AGING CAN HELP!

REGENERATIVE MEDICINE AND KNEE PAIN

Modern medicine often relies on medications that only mask pain rather than promoting true healing. Too many people are prescribed surgeries that may not effectively resolve their pain or the underlying problem.

Surgery itself is highly invasive—requiring tools that seem better suited for a construction site than the human body. That’s why it’s called surgical reconstruction. Recovery can take months or even years, and in many cases, the joint never fully feels or functions as it once did.

Joint replacement surgery introduces foreign materials into the body, which can create long-term issues. Just like your body reacts to a splinter—trying to push it out—your immune system may respond to implants with inflammation and pain, as it doesn’t recognize them as part of its natural structure.

At Rejuve Anti Aging, our regenerative therapies work with your body’s natural healing abilities. Using cutting-edge techniques, we concentrate and precisely deliver your body’s own regenerative cells to areas in need of repair, helping to restore function and reduce pain—without surgery. This approach, known as regenerative orthopedic medicine, has helped thousands regain mobility and live more active, pain-free lives.

100%

Saw improvement in pain scores in just 1 month!

120 participant results measured in 1-month follow ups following mesenchymal stem cell injections, compared to baseline.

Up to 76% Average Function Regained and Overall Pain Improvement

Frequently Asked Questions

What are Mesenchymal Stem Cells (MSCs)

Mesenchymal Stem Cells (MSCs) are undifferentiated cells capable of developing into diverse cell lineages. These cells maintain the capacity for self-renewal and are highly responsive to their surrounding environment. Upon receiving specific signals, they commit to differentiation pathways, transforming into specialized cells like skin, muscle, cartilage, tendon, bone, or red blood cells. Augmenting the availability of stem cells at a site of injury or damage can significantly promote optimal tissue regeneration by ensuring an ample supply of cells for repair.

What makes mesenchymal stem cells (MSCs) useful in a clinical setting?

Mesenchymal stem cells (MSCs) are increasingly utilized in treating a range of diseases due to their remarkable properties. These include self-renewal (the ability to create more stem cells), differentiation (the process of maturing into specialized cells with distinct form and function; for example, an MSC can develop into various cell types), anti-inflammatory effects (reducing harmful inflammation), and immunomodulation (regulating the immune system). Immunomodulation is particularly important, as MSCs can both stimulate a weak immune response and dampen an overactive one, potentially preventing the autoimmune reactions seen in many disorders. The anti-inflammatory capabilities of MSCs are crucial, as while inflammation is a natural defense mechanism, chronic or excessive inflammation can damage the body.

Extensive research, including both in-vitro (laboratory-based) and in-vivo (within a living organism) studies, has supported the safety and efficacy of MSC therapy and continues to elucidate the underlying mechanisms. This research highlights the diverse capabilities of MSCs, enabling their use in a variety of clinical settings for numerous degenerative conditions.

Emerging evidence suggests that umbilical cord tissue-derived MSCs (UC-MSCs) may possess greater potency compared to MSCs from other sources, potentially leading to enhanced clinical effectiveness.

Are there ethical issues involving this form of stem cell therapy?

Adult mesenchymal stem cells (MSCs) do not raise the same ethical concerns as fetal and embryonic stem cells. Both the Catholic Church and the Southern Baptist Convention have endorsed the research and therapeutic use of adult stem cells as an ethically acceptable alternative.

Why use umbilical cord tissue-derived mesenchymal stem cells (UC-MSCs)?

Advantages of Umbilical Cord Tissue-Derived Mesenchymal Stem Cells (UC-MSCs)

Umbilical cord tissue-derived mesenchymal stem cells (UC-MSCs) offer several advantages over other sources of MSCs, such as bone marrow-derived MSCs (BM-MSCs) and adipose-derived stem cells (ASCs):

  • Superior Proliferation: UC-MSCs exhibit a significantly higher proliferation rate in vitro (in a laboratory setting) compared to BM-MSCs and ASCs. This allows for more efficient expansion to obtain the large cell numbers needed for therapeutic applications.

  • Non-Invasive Harvesting: The collection of UC-MSCs is non-invasive. The cells are obtained from ethically donated umbilical cord tissue after birth, a process that poses no risk or discomfort to either the mother or the newborn. This contrasts with BM-MSC harvesting, which requires a bone marrow aspiration, and ASC harvesting, which typically involves liposuction.

  • Enhanced Secretion of Beneficial Factors: UC-MSCs secrete a variety of growth factors, cytokines, and chemokines. These secreted factors play a crucial role in tissue repair, reducing inflammation, and modulating the immune system.

  • Differentiation Potential: Like other MSCs, UC-MSCs can differentiate into various cell types, contributing to tissue regeneration.

  • Upregulated Genes: Research indicates that certain genes associated with cell proliferation (e.g., EGF), signaling pathways involved in cell survival and growth (e.g., PI3K-NFkB pathway via TEK), and neurogenesis (e.g., RTN1, NPPB, NRP2) are upregulated (have increased activity) in UC-MSCs compared to BM-MSCs. This suggests a potentially greater capacity for tissue repair and regeneration.

Is regenerative medicine being used to treat patients yet?

Yes! In recent years, several regenerative medicine treatments have been introduced into clinical practice for pain management and orthopedic care. These treatments utilize adult stem cells, making them non-controversial. The available procedures include:

  • Platelet-Rich Plasma (PRP) Therapy
  • Mesenchymal Stem Cell-Rich Injections
  • Bone Marrow-Derived Stem Cell Injections
  • Fat-Derived Stem Cell Injections

Regenerative medicine may offer benefits for various medical conditions, including:

    • Joint arthritis
    • Tennis elbow (lateral epicondylitis)
    • Golfer’s elbow (medial epicondylitis)
    • Rotator cuff tendonitis
    • Ligament sprains
    • Fractures
    • Tendon injuries
    • Cartilage defects
    • COPD
    • Kidney failure
    • Stroke
    • Multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS)
    • Dementia
    • Erectile dysfunction
    • Heart failure
    • Diabetes
    • Diabetic neuropathy
Is there any chance my body rejects mesenchymal stem cells (MSCs)?

MSCs possess immunosuppressive properties, reducing the likelihood of immune rejection compared to other foreign cells. Umbilical cord tissue-derived MSCs (UC-MSCs) are particularly immune-privileged, meaning they are universally accepted by the recipient’s body with virtually no risk of rejection. This is because UC-MSCs are essentially “new” and haven’t been “claimed” by a specific immune system. Unlike organ transplantation, UC-MSC therapy doesn’t require blood products or HLA matching.

Does insurance cover regenerative medicine therapy?

Regenerative medicine procedures are generally not covered by insurance. While some surgical applications may have billing codes, most treatments are considered out-of-pocket expenses.

How much do regenerative medcine treatments cost?

The price range for regenerative medicine injections is broad, typically between $1,500 and $7,500.

Who is a Candidate for Stem Cell Therapy?

Our protocol is designed to significantly reduce chronic low-grade inflammation over an extended period. Stem cells possess a unique ability to target areas of inflammation in the body. Research indicates that they can regenerate damaged or diseased tissues, decrease inflammation, and regulate the immune system—contributing to improved health and overall quality of life.

Studies suggest that mesenchymal stem cells (MSCs) may have a positive impact on various conditions, including:

  • ALS
  • Alzheimer’s disease
  • Autoimmune disorders
  • COPD and other degenerative/inflammatory lung diseases
  • COVID-19 (acute and long-haul)
  • Chronic inflammation
  • Crohn’s disease
  • Type 1 diabetes
  • Heart failure and heart disease
  • Kidney disease
  • Liver disease
  • Lupus
  • Lyme disease
  • Multiple sclerosis
  • Degenerative neurological conditions
  • Neuropathy
  • Parkinson’s disease
  • Reflex Sympathetic Dystrophy (RSD) / Complex Regional Pain Syndrome (CRPS)
  • Rheumatoid arthritis
  • Spinal cord injuries
  • Stroke (ischemic and hemiplegic)
  • Traumatic brain injury (TBI)
How many sessions will I need?

Our protocol aims for long-term stabilization of the condition with a single treatment. Follow-up treatments are not required. While some patients choose to return for additional treatments, typically seeking further improvement, generally one treatment is sufficient for most degenerative conditions.

Will the treatment be painful?

Patients generally report minimal discomfort during treatment, often describing the experience as painless. 

When will I start seeing results?

While individual responses vary, many study participants report noticeable improvements within 1-3 months after treatment. These improvements are evidenced by reduced systemic inflammation and increased vitality, as measured by follow-up questionnaires. Some patients report improvements in symptoms and quality of life even sooner, within the first few days post-treatment.

Do stem cells get trapped in the lungs? (Pulmonary first pass effect)

Umbilical cord-derived mesenchymal stem cells (UC-MSCs) are particularly effective for systemic delivery via intravenous infusion. Their optimal size (17-19 micrometers) allows for efficient passage through the circulatory system, including the lungs. Although a portion of MSCs may initially be trapped in the lungs (a phenomenon known as the pulmonary first-pass effect), this does not negate their therapeutic benefits. MSCs possess a remarkable homing ability – they can actively migrate to damaged tissues. Even while temporarily in the lungs, MSCs exert beneficial paracrine effects: they secrete growth factors and other molecules that reduce inflammation and stimulate tissue repair. Advances in research are continually enhancing the delivery and efficacy of MSCs for regenerative therapies.

Can stem cells help prevent aging?

Potential of Stem Cells in Anti-Aging and Rejuvenation

Current research suggests that stem cell therapies may have the potential to mitigate some effects of aging and improve overall healthspan. Stem cells, particularly mesenchymal stem cells (MSCs), possess properties that could contribute to this, including their ability to:

  • Repair damaged tissues: Stem cells can differentiate into various cell types, potentially replacing aged or damaged cells.
  • Reduce inflammation: Chronic inflammation is a key contributor to age-related decline, and MSCs have anti-inflammatory effects.
  • Modulate the immune system: MSCs can help regulate immune function, which often declines with age.
  • Homing Capability: Stem cells can migrate to sites of damage or inflammation.

The concept of a “protective shield” created by stem cells and anti-aging genes is a simplified representation of these complex biological processes. While a complete reversal of aging is not currently feasible, studies suggest that stem cell interventions, potentially in combination with therapies targeting aging-related genes, could contribute to a healthier and potentially longer lifespan. It’s crucial to understand that this is an area of ongoing research, and many claims about “anti-aging” stem cell treatments are not yet supported by robust clinical evidence.

Potential Benefits of Stem Cell Therapy (Observed and Reported):

Some reported benefits of stem cell therapies, particularly in the context of age-related decline, include:

  • Increased energy and vitality
  • Improved physical capacity and endurance
  • Improved hair quality and thickness
  • Enhanced libido
  • Pain reduction
  • Increased strength, balance, and overall mobility
  • Enhanced immune function
  • Overall improvement in quality of life
  • Reduced inflammatory markers
Can MSCs cause Graft vs. Host Disease?

Mesenchymal stem cells (MSCs) are not a cause of graft-versus-host disease (GVHD); in fact, they are being investigated as a potential treatment for this condition. GVHD is a serious complication that can occur after allogeneic hematopoietic stem cell transplantation (typically bone marrow or cord blood transplants), where the donor’s immune cells (T-cells) attack the recipient’s tissues.

MSCs possess immunomodulatory properties that make them promising candidates for GVHD therapy. They achieve this through several mechanisms, including:

  • Secretion of bioactive molecules: MSCs release proteins, peptides, and hormones that can suppress the immune response.
  • Mitochondrial transfer: MSCs can transfer mitochondria (the energy-producing components of cells) to damaged cells, potentially aiding in tissue repair.
  • Exosome and microvesicle release: MSCs release small vesicles containing RNA and other molecules that can influence the behavior of recipient cells, including immune cells.

While many studies suggest that MSC therapy can be beneficial for both acute and chronic GVHD, more extensive, large-scale, randomized controlled trials are needed to definitively confirm these findings and establish optimal treatment protocols.

It is important to clarify a distinction: although MSCs can modulate the activity of immune cells like T-lymphocytes and B-lymphocytes (reducing their proliferation and secretion of inflammatory factors), they are not broadly immunosuppressive in the same way as traditional immunosuppressant drugs. They have targeted immunomodulatory effects, rather than causing widespread immune suppression. This targeted effect is one reason they are promising for treating GVHD.

What is your success rate?

Follow-up vitality questionnaires indicate that approximately 85% of patients report sustained improvement in their condition within three months of treatment.

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