Nicotinamide adenine dinucleotide (NAD) is a coenzyme essential for various metabolic processes, including energy production and DNA repair. Researchers are uncovering new ways in which NAD+ supports healthy aging and longevity. However, NAD+ levels significantly decline with age, leading to an energy shortfall that reduces the body’s capacity to maintain youthful functions.
For instance, by age 50, a typical person may have only about half the NAD+ levels they had in their youth. By age 80, these levels can drop to just 1% to 10% of youthful levels. A deficiency in NAD+ accelerates aging and diminishes the effectiveness of compounds like resveratrol.
The good news is that restoring your cellular NAD+ to healthier levels is relatively simple.
You might not realize it, but there is a coenzyme present in every living cell of your body that is essential for your survival—NAD+ (nicotinamide adenine dinucleotide). Without NAD+, your body wouldn’t be able to transfer energy from the food you eat to your cells, particularly in vital organs like the brain.
Beyond energy transfer, NAD+ is also crucial for regulating genes involved in the aging process. Unfortunately, NAD+ levels naturally decrease as you age and can decline even faster due to factors like lifestyle, diet, alcohol consumption, stress, and exposure to toxins.
The good news is that there is a way to counteract the many symptoms of aging. NAD+ IV therapy is an intravenous treatment that works at the cellular level to provide rejuvenating benefits. It can boost overall energy, enhance metabolism and weight loss, improve mental clarity, and even help reduce fine lines and wrinkles.
The NAD+ IV infusion protocol provides several significant advantages:
Slows Down the Aging Process: By replenishing NAD+ levels, this specialized vitamin therapy targets aging at the cellular level, helping you look and feel younger.
Boosts Metabolism and Aids in Weight Loss: As we age, metabolism naturally slows down, often leading to weight gain. NAD+ IV therapy helps restore normal metabolic function, promoting weight loss and increasing overall energy.
Enhances Brain Function and Mental Clarity: Cognitive abilities tend to decline with age, but NAD+ IV therapy can improve concentration, focus, memory, and mood. This leads to greater productivity, better decision-making, and a higher quality of life.
Combats Fatigue and Boosts Energy Levels: Decreased NAD+ levels are often linked with low energy and motivation. NAD+ IV therapy provides the energy needed at the cellular level, helping to combat fatigue.
Repairs Skin Damage: Overexposure to UV rays can damage skin cells, leading to pigmentation, fine lines, and sometimes skin cancer. NAD+ helps repair damaged DNA, contributing to healthier and younger-looking skin.
Reduces Inflammation and Protects Cells: NAD+ IV therapy helps activate enzymes that repair DNA damage caused by inflammation, harmful foods, pollutants, and toxic chemicals, reducing cellular damage.
Eases Stress: Oxidative stress—caused by an imbalance between free radicals and antioxidants—along with the stress of modern life, can deplete your body’s NAD+ levels. NAD+ IV infusions restore this essential coenzyme, helping the body resist the negative effects of stress and anxiety.
NAD can slow the aging process while also supporting the body in many other ways. If you’re ready to feel better than ever, it’s time to schedule NAD treatment! The best and most efficient way to provide the body with NAD is through NAD IV Therapy Treatment.
IV therapy and nutrition are ways for the body to receive infusions of different vitamins and supplements through an IV. There are many different reasons to get an IV drip, but they all strive to improve your health and overall feeling of wellness.
NAD IV treatments supplement and restore the levels of NAD in your body with NAD+ supplementation. A specialized saline solution containing a concentrated dose of NAD is delivered directly into the bloodstream, where it’s converted to NADH. It’s then available to your cells for immediate use (potentially increasing cellular energy production and supporting DNA repair).
The process of receiving a NAD drip is simple and painless: a medical professional gently inserts a needle into your arm and then connects it to the tubing that leads to the drip bag. You can sit comfortably during the treatment and listen to music, read a book, or watch a video on a personal device.
Infusing your body with NAD through drip is the only way for your body to absorb 100% of the bioavailability from the NAD molecule. NAD drips are a much more efficient way of supplementing this coenzyme because oral supplements have to pass through the digestive system first before activating.
There is growing evidence that supplementing with NAD+ can promote longevity in life forms ranging from simple worms to mammals like mice.
One study showed an average 5% increase in the lifespan of old mice—even though supplementation did not begin until the mice were nearing the end of their natural lifespan (24 months).
That would be the equivalent of gaining nearly an additional four years of life based on today’s average human expectancy of 78.8 years.
A rigorous scientific review of NAD+ reveals that its longevity benefits arise from these 8 different, but interrelated, functions:
NAD+ is required for functioning of sirtuins – proteins that contribute to longevity by maintaining the length of critical telomeres.
Telomeres are stretches of repetitive DNA strands that cap the ends of chromosomes. Like the burning of a fuse, telomeres at the ends of our chromosomes steadily shorten every time a cell replicates itself. Once telomeres reach a critically short length, cell renewal virtually stops, leading to accelerated aging or death of the cell.
Telomere shortening is both a marker of cellular aging and a predictor of shortened lifespan.
Researchers have been searching for drugs and other interventions that might lengthen telomeres, in order to extend lifespan and/or health span. To date, exercise and weight loss have been reliably shown to be effective at telomere lengthening.
Certain other nutrients, such as resveratrol, may activate sirtuins and contribute to extending lifespan, but emerging evidence suggests sirtuins function best with an ample supply of NAD+.
Conclusion: The possibility of extending telomere length with NAD+ holds out hope for slowing the aging process and improving longevity.
Even though DNA is protected by its chromosomal shelter, it is highly vulnerable to damage.
This can lead to broken DNA strands and mutations in crucial genes. Accumulated DNA damage contributes to the aging process and can result in specific lifespan-shortening diseases like cancer and poor immune function.18
When DNA is damaged, it activates an enzyme known as PARP-1 that carries out DNA repair within cells. To carry out its function, PARP-1 consumes enormous amounts of NAD+. As NAD+ is depleted, the ability of PARP-1 to repair DNA is significantly hindered.
The good news is that replenishing NAD+ to cells can restore DNA repair and prevent cell death under stress. In two different animal models of neurodegenerative disease, increasing cellular NAD+ reduced the severity of the disorder, normalized neuromuscular function, delayed memory loss, and extended lifespan.
Conclusion: Improving DNA repair with NAD+ may slow cellular aging, reduce the persistence of cancer-causing mutations, and play an important role in preventing inflammatory conditions such as atherosclerosis.
As we age, our immune cells begin to lose their focus. Some become overactive, contributing to autoimmune disease, while others slow down, which increases the risk of infection. This process, called immunosenescence, is intimately related to mitochondrial function and energy balance, both of which depend on NAD+ activity.
Intracellular levels of NAD+ regulate immune and inflammatory pathways, including the cytokine TNF-alpha, a critical signaling molecule.
Conclusion: Adequate intracellular NAD+ is vital for youthful cellular energy, a critically important factor in fending off immunosenescence and maintaining defenses against infections and autoimmune disease.
A universal feature of aging is the loss of cellular energy, which results in diminished ATP levels and inadequate cellular fuel necessary to power your body.
One cause of this energy loss is a breakdown in the efficiency of the electron transport chain, the main pathway through which we extract energy from food (and of which NAD+ is an essential component). Disorders ranging from obesity and diabetes to bone loss have been associated with loss of this vital pathway.
Studies now show that restoring electron transport chain function by raising levels of NAD+ is a rapid and efficient means of promoting the essential enzymes involved in energy extraction and sustaining youthful cell function. This helps to reduce physiological decline and provides protection from age-related disease.
Conclusion: Improving the energy-extraction process in all cells with NAD+ increases their capacity to do the work they are specialized for. It also protects mitochondria from early death, a benefit that is associated with reduced cellular aging and lowered risks for cardiovascular and brain disease.
Our chromosomes are complex structures housing our DNA. Access to DNA strands for “reading out” genetic instructions requires biochemical control of those proteins to make sure each gene functions properly.
But like any complex molecular structure, chromosomes can become unstable. Eventually, this triggers errors in the ways our genes are interpreted—which ultimately contributes to deleterious changes in cell function and structure. Aging is accelerated in the presence of increased chromosome instability.
The enzymes involved in sustaining stable chromosomal structures require NAD+ in order to function properly.
In animal models showing that NAD+ contributes to longevity, a major factor has been shown to be sufficient availability of the nutrient. And studies show that when enzymes that require NAD+ are inactive, chromosome structure suffers and cells replicate abnormally.
Conclusion: NAD+ supplementation is a promising cutting edge strategy to improve chromosome stability, a treatment that may slow down cellular aging (senescence) and lower the risk of cancer.
Neurotransmitters are brain chemicals that relay signals between nerve cells. In doing so, they help regulate body-wide functions such as mood, appetite, and stress.
NAD+ has been found to meet all criteria for a neurotransmitter.
Evidence for NAD+’s neurotransmitter function has now been found in intestinal and blood vessel smooth muscles, as well as in the brain itself.
Conclusion: Ample NAD+ nutrition appears essential for sustaining brain health.
Proteins called sirtuins are major regulators of cellular aging because they influence fundamental functions such as DNA repair and inflammatory responses. They also influence whether cells enter a replicative cycle or instead die a programmed death (apoptosis).
Compounds that activate sirtuins are eagerly sought as chemical “fountains of youth.” Familiar supplements like resveratrol and quercetin have been evaluated as promising sirtuin activators.
NAD+ is required for sirtuins to function.
Conclusion: Sirtuin activation has shown great promise in fighting cardiovascular disease and preserving aging brain function, but these longevity-promoters cannot function without sufficient NAD+.
NAD+ was first discovered as an important part of the process that channels chemical energy from foods to the ATP fuel our cells require. Recent studies have revealed that NAD+ is itself a form of “energy currency” similar to ATP.
NAD+ is also a functional signaling molecule in processes related to energy production, including PARP-1 and sirtuins. When DNA damage occurs, PARP-1 consumes large quantities of NAD+, leading to reduced energy production. In addition, high levels of NAD+ can activate sirtuins, permitting them to carry out their metabolic and stress-protective responses and contributing to longevity.
Conclusion: Supporting efficient energy production and adequate ATP levels requires consistent and abundant NAD+. This is critical because waning energy supplies contribute to the aging process.
Indication | NAD+ | Course | Interval time |
---|---|---|---|
Anti Aging | NAD+ 250mg | 4 times | Once a week |
Neurogenerative Benefit | NAD+ 500mg | 4 times | Once a week |
Addiction Detox | NAD+ 750mg | 4 times | Once a week |
Boost | – | – | Every 1-2 month |
NAD+ Infusion therapy is a type of intravenous (IV) treatment that can stimulate cell regeneration in your body. It simply involves infusing a high dose of the compound directly into your bloodstream – which is a faster and more effective treatment than other delivery systems – thereby restoring your own cells’ NAD levels and providing you with more immediate energy and vitality. During your infusion, NAD molecules bind with proteins in your body to create active enzymes that your body then uses to metabolize fuel and revitalize cells.
Oral supplementation is less effective than infusion for boosting NAD levels because the digestion process reduces the amount of NAD+ precursors that the body can absorb. Additionally, NAD+ is an unstable molecule when placed in a capsule and exposed to gastric acid. NAD+ infusion bypasses the intestinal tract, allowing the body to fully absorb and utilize the molecule. Infusion provides the building blocks of NAD+, which the body then uses to produce NAD+.
Besides promoting generally healthier aging, NAD+ infusion therapy can help treat a number of mental health issues – such as anxiety, mood disorders, substance abuse disorders, post-traumatic stress disorder (PTSD). Because of its ability to support enzymatic functions, it has been found to be effective in treating Lyme disease.
Since NAD is a natural substance that your body continuously uses and easily incorporates, infusion therapy is a completely safe treatment option.
During the infusion, NAD+ can cause mild to moderate side effects such as nausea, headaches, cramping, chest tightness, anxiety, body warmth and muscle fatigue. Most of these side effects can be relieved by slowing the IV drip rate. We will help you find a drip rate that works well for you as these side effects tend to be patient-specific. Once slowed the side effects tend to resolve within seconds.
You can eat and drink before your infusion, although eating junk food is not recommended.
Not at all! You can resume your normal activities immediately after your appointment.
Oral NAD+ is poorly absorbed and is not a viable option.
With IV NAD+ however you are able to achieve much higher plasma concentrations of NAD+ that would not be possible with oral supplementation alone. IV therapy allows you to completely bypass gastric absorption and liver first pass metabolism.
NAD+ is not a psychoactive substance and therefore no specific requirements for what you can or cannot do before NAD+ treatment. You can go about your day-to-day activities as usual. You can also return to work after the session if you wish. You do not need a driver and can drive yourself home after your infusion.