Rejuve Anti Aging Medical Spa in Rancho Santa Margarita
STEM CELL JOINT INJECTIONS
SHOULDER PAIN
Regenerative medicine treatments may offer a superior alternative to shoulder surgery
The shoulder joint, while remarkably mobile, sacrifices stability. This inherent trade-off makes it vulnerable to injuries like rotator cuff tears, dislocations, and labral damage, as well as degenerative conditions such as osteoarthritis. While surgery is often considered for pain relief and functional restoration, research indicates that its effectiveness varies significantly, and it comes with potential risks and lengthy recovery periods.
For those seeking alternatives to traditional surgery, Rejuve Anti Aging offers cutting-edge regenerative therapies designed to address shoulder pain and injuries. Our advanced trifecta joint injections—combining PRP, Stem Cells, and Exosomes—provide a sophisticated, non-surgical solution. By harnessing your body’s natural healing capabilities, these treatments stimulate tissue repair and regeneration, targeting the root cause of shoulder problems.
Whether you’re an athlete aiming to return to peak performance, an individual experiencing chronic shoulder discomfort, or simply looking to maintain optimal mobility, Rejuve’s regenerative therapies can help you regain strength and flexibility. Experience a revitalized, pain-free life and potentially delay or avoid invasive shoulder surgery.
Rejuve Anti Aging also provides ultrasound-guided stem cell injections, a precise, image-guided approach using your own Mesenchymal Stem Cells to repair damaged shoulder tissues. This innovative method promotes natural healing and improved function, minimizing the risks and drawbacks associated with conventional surgical interventions. Rediscover youthful shoulder mobility and explore the potential of regenerative medicine.
Rotator cuff tears - Labrum tears/SLAP tears - Osteoarthritis - Separated shoulders
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PROVEN RESULTS
Stem cell therapy: clinically proven to reduce joint pain and improve mobility.
NATURAL & SAFE
Leveraging the body’s own processes combined with PRP, Stem Cells and Exosomes
SIMPLE 30 MIN PROCEDURE
Ultrasound guided, highly accurate joint injections without anesthesia or downtime.
100% GUARANTEE OF SHOULDER PAIN REDUCTION!
Details Available During The Consultation
Clinical Studies Of Stem Cells and Shoulder Injuries
The past decade has witnessed a significant surge in research and publications concerning the therapeutic application of mesenchymal stem cells for shoulder injuries and conditions . This extensive body of work highlights the intense interest and ongoing research efforts dedicated to understanding and optimizing this therapeutic approach. A notable trend in recent years is the increasing focus on elucidating the precise mechanisms of action of MSCs, moving beyond the initial understanding of their differentiation potential to explore the critical roles of paracrine signaling and immunomodulation. The growing number of clinical trials investigating MSC therapy for various shoulder conditions reflects a concerted effort to translate promising preclinical findings into tangible benefits for patients suffering from these debilitating injuries.
"Use of stem cells and growth factors in rotator cuff tendon repair"
Journal of Shoulder & Elbow Surgery
“We have identified Stem Cells as a key player in RCT repair”
"100 % of the repairs with MSC had healed versus 67 % of the repairs without MSC by 6 months"
Internaltional Orthopedics
MSC’s enhanced rate of healing and the reduced number of re-tears
"115 shoulders in 102 patients were treated for symptomatic OA and/or rotator cuff tears...significant results"
Journal of Pain Research
A comprehensive review
End Shoulder Pain!
Have you been told that the only way to relieve your shoulder pain is through steroid injections or invasive surgery?
Research suggests that many common shoulder surgeries, like certain rotator cuff repairs or subacromial decompressions, may not provide significantly more benefit than placebo treatments. This raises questions about their true efficacy in alleviating pain and restoring function.
While shoulder surgeries are sometimes essential, they are highly invasive procedures with considerable risks. The demanding rehabilitation process and the potential for accelerated joint degeneration, which can exacerbate long-term problems, challenge the overall suitability of these surgeries, especially when considering the range of alternative treatment options available.
Stem Cell Therapy Could Be The Exact Non-Surgical Alternative You’ve Been Waiting For!
Reclaim your active lifestyle. Rejuve Anti-Aging offers non-surgical solutions to get you back to the activities you love.
The fear is real: a sudden, sharp pain, your shoulder giving way, an unexpected jolt. The uncertainty of every reach keeps you on edge, forcing you to second-guess simple movements. Imagine missing out on life’s most precious moments—unable to lift your grandchild, hesitating to participate in your favorite activities, or declining invitations for fear your shoulder might fail.
For months, the instability, the persistent ache, and the limited range of motion have held you back, making even routine activities feel risky. The thought of invasive surgery looms over you, with its long recovery times and uncertain outcomes. But what if there was another way?
At Rejuve Anti Aging, we understand the frustration and fear that come with shoulder pain and instability. That’s why we offer cutting-edge, non-surgical regenerative solutions designed to support your body’s natural healing process. With advanced treatments like PRP, Stem Cells, and Exosomes, we help you regain confidence, stability, and mobility—so you can reclaim your active lifestyle without the fear of surgery. Let us guide you toward a future of movement, strength, and freedom.
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Outcomes For Knee Stem Cell Knee Procedures
COMMON SHOULDER CONDITIONS TREATED WITH STEM CELLS JOINT INJECTIONS AT REJUVE ANTI AGING
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Torn Rotator Cuff
Rotator cuff tears occur when the tendons surrounding the shoulder joint are damaged, often due to overuse, traumatic injury, or age-related degeneration. This condition manifests as pain, weakness, and restricted movement, significantly hindering daily activities like lifting and reaching.
While many individuals rely on medication to manage these symptoms, a 2024 study has highlighted the correlation between shoulder injuries and increased opioid usage. However, medication, while providing temporary relief, does not address the underlying tendon damage and may ultimately lead to the necessity of surgical intervention as the condition progresses.
Several factors increase the risk of rotator cuff tears:
Poor posture: Slouching and rounded shoulders place excessive strain on the rotator cuff, leading to muscle imbalances and uneven joint wear, significantly increasing the risk of tears. A 2015 study indicated that approximately 56% of individuals with poor posture experienced rotator cuff tears, compared to only 2.9% of those with proper posture.
Family history: Genetic predisposition to tendon weakness or degeneration can increase susceptibility to rotator cuff injuries. A 2017 systematic review revealed that about one-third of patients with rotator cuff tears had a family history of the condition.
Age 40 and older: Natural age-related weakening and loss of elasticity in shoulder tendons increases the likelihood of tears.
Repetitive overhead activities: Athletes and laborers engaging in repetitive overhead movements, such as swimmers, baseball players, painters, and carpenters, are at higher risk due to the constant strain on the shoulder joint.
Gender: Women may have a higher prevalence of rotator cuff problems due to increased joint mobility and a greater risk of osteoarthritis. A study involving 1,003 women aged 64-87 found that 22% had rotator cuff tears, with prevalence increasing with age and affecting the dominant arm more frequently.
Untreated rotator cuff tears can lead to serious complications, including chronic pain, further damage to the shoulder joint, significant limitations in mobility and function, and loss of muscle strength. Additionally, prolonged neglect can result in arthritis or other joint-related issues, and the likelihood of requiring surgery increases as the tear worsens.
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Torn Labrum Shoulder Without Surgery
The shoulder labrum, a crucial ring of cartilage, deepens the shoulder socket (glenoid) and enhances joint stability. It acts as a protective buffer, connecting the humerus (upper arm bone) to the scapula (shoulder blade), and facilitates smooth, pain-free movement.
Labral tears can arise from acute trauma, like falls or car accidents, or from chronic wear and tear. A less recognized cause is shoulder instability, which can develop gradually after minor injuries or seemingly innocuous events. Picture the humerus as a bowling ball and the labrum as the lane's gutter guard. In a stable shoulder, the "ball" moves smoothly. In an unstable shoulder, the "ball" repeatedly impacts the "guard" (labrum), leading to tears.
Surgical repair of labral tears often involves invasive procedures and lengthy, painful rehabilitation. However, it frequently fails to address underlying instability, potentially leading to recurrent injuries and limited functional improvement. Notably, a high-quality study comparing labral repair to a placebo procedure found no significant difference in outcomes, raising questions about the surgery's overall effectiveness.
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Treating Shoulder Arthritis Without Surgery
Shoulder arthritis, a condition affecting nearly 25% of the adult population, presents a significant challenge due to the limitations of many conventional treatments. Despite its prevalence, patients often find that standard approaches yield less than satisfactory outcomes.Studies consistently demonstrate the unreliability of surgical interventions, highlighting the variability in patient response and potential for complications. Furthermore, commonly employed non-surgical alternatives, such as corticosteroid injections, which are intended to provide temporary pain relief, can paradoxically contribute to long-term joint deterioration.Research indicates that steroids can accelerate cartilage breakdown and induce chondrocyte death, ultimately worsening the arthritic condition over time. This underscores the need for more effective and less damaging therapeutic strategies in managing shoulder arthritis.
SHOULDER JOINT HEALTH
The human body is designed to heal itself. Your body’s natural goal is repair and regeneration. A simple example is when you get a cut—your body stops the bleeding, forms a scab, and sends healing cells to close the wound.
This self-healing ability is constantly at work, even when you can’t see it. Your body is always scanning for damage and sending repair cells where they’re needed. However, certain factors influence how effectively your body can heal, including:
- Smoking habits
- Alcohol consumption
- Sleep quality and duration
- Regular physical activity
- Nutrition and digestion
- Stress management
Even with a healthy lifestyle—eating well, exercising, and getting enough rest—there are times when your body needs extra support. That’s where regenerative therapies at Rejuve Anti Aging can help. Our advanced treatments, including stem cell therapy and PRF, work with your body’s natural healing processes to restore function, reduce pain, and promote long-term wellness.
AND THAT’S WHERE REJUVE ANTI AGING CAN HELP!
REGENERATIVE MEDICINE AND SHOULDER PAIN
Modern medicine often relies on medications that only mask pain rather than promoting true healing. Too many people are prescribed surgeries that may not effectively resolve their pain or the underlying problem.
Surgery itself is highly invasive—requiring tools that seem better suited for a construction site than the human body. That’s why it’s called surgical reconstruction. Recovery can take months or even years, and in many cases, the joint never fully feels or functions as it once did.
Joint replacement surgery introduces foreign materials into the body, which can create long-term issues. Just like your body reacts to a splinter—trying to push it out—your immune system may respond to implants with inflammation and pain, as it doesn’t recognize them as part of its natural structure.
At Rejuve Anti Aging, our regenerative therapies work with your body’s natural healing abilities. Using cutting-edge techniques, we concentrate and precisely deliver your body’s own regenerative cells to areas in need of repair, helping to restore function and reduce pain—without surgery. This approach, known as regenerative orthopedic medicine, has helped thousands regain mobility and live more active, pain-free lives.
100%
Saw improvement in pain scores in just 1 month!
120 participant results measured in 1-month follow ups following mesenchymal stem cell injections, compared to baseline.
Up to 76% Average Function Regained and Overall Pain Improvement
Frequently Asked Questions
Mesenchymal Stem Cells (MSCs) are undifferentiated cells capable of developing into diverse cell lineages. These cells maintain the capacity for self-renewal and are highly responsive to their surrounding environment. Upon receiving specific signals, they commit to differentiation pathways, transforming into specialized cells like skin, muscle, cartilage, tendon, bone, or red blood cells. Augmenting the availability of stem cells at a site of injury or damage can significantly promote optimal tissue regeneration by ensuring an ample supply of cells for repair.
Mesenchymal stem cells (MSCs) are increasingly utilized in treating a range of diseases due to their remarkable properties. These include self-renewal (the ability to create more stem cells), differentiation (the process of maturing into specialized cells with distinct form and function; for example, an MSC can develop into various cell types), anti-inflammatory effects (reducing harmful inflammation), and immunomodulation (regulating the immune system). Immunomodulation is particularly important, as MSCs can both stimulate a weak immune response and dampen an overactive one, potentially preventing the autoimmune reactions seen in many disorders. The anti-inflammatory capabilities of MSCs are crucial, as while inflammation is a natural defense mechanism, chronic or excessive inflammation can damage the body.
Extensive research, including both in-vitro (laboratory-based) and in-vivo (within a living organism) studies, has supported the safety and efficacy of MSC therapy and continues to elucidate the underlying mechanisms. This research highlights the diverse capabilities of MSCs, enabling their use in a variety of clinical settings for numerous degenerative conditions.
Emerging evidence suggests that umbilical cord tissue-derived MSCs (UC-MSCs) may possess greater potency compared to MSCs from other sources, potentially leading to enhanced clinical effectiveness.
Adult mesenchymal stem cells (MSCs) do not raise the same ethical concerns as fetal and embryonic stem cells. Both the Catholic Church and the Southern Baptist Convention have endorsed the research and therapeutic use of adult stem cells as an ethically acceptable alternative.
Advantages of Umbilical Cord Tissue-Derived Mesenchymal Stem Cells (UC-MSCs)
Umbilical cord tissue-derived mesenchymal stem cells (UC-MSCs) offer several advantages over other sources of MSCs, such as bone marrow-derived MSCs (BM-MSCs) and adipose-derived stem cells (ASCs):
Superior Proliferation: UC-MSCs exhibit a significantly higher proliferation rate in vitro (in a laboratory setting) compared to BM-MSCs and ASCs. This allows for more efficient expansion to obtain the large cell numbers needed for therapeutic applications.
Non-Invasive Harvesting: The collection of UC-MSCs is non-invasive. The cells are obtained from ethically donated umbilical cord tissue after birth, a process that poses no risk or discomfort to either the mother or the newborn. This contrasts with BM-MSC harvesting, which requires a bone marrow aspiration, and ASC harvesting, which typically involves liposuction.
Enhanced Secretion of Beneficial Factors: UC-MSCs secrete a variety of growth factors, cytokines, and chemokines. These secreted factors play a crucial role in tissue repair, reducing inflammation, and modulating the immune system.
Differentiation Potential: Like other MSCs, UC-MSCs can differentiate into various cell types, contributing to tissue regeneration.
Upregulated Genes: Research indicates that certain genes associated with cell proliferation (e.g., EGF), signaling pathways involved in cell survival and growth (e.g., PI3K-NFkB pathway via TEK), and neurogenesis (e.g., RTN1, NPPB, NRP2) are upregulated (have increased activity) in UC-MSCs compared to BM-MSCs. This suggests a potentially greater capacity for tissue repair and regeneration.
Yes! In recent years, several regenerative medicine treatments have been introduced into clinical practice for pain management and orthopedic care. These treatments utilize adult stem cells, making them non-controversial. The available procedures include:
- Platelet-Rich Plasma (PRP) Therapy
- Mesenchymal Stem Cell-Rich Injections
- Bone Marrow-Derived Stem Cell Injections
- Fat-Derived Stem Cell Injections
Regenerative medicine may offer benefits for various medical conditions, including:
- Joint arthritis
- Tennis elbow (lateral epicondylitis)
- Golfer’s elbow (medial epicondylitis)
- Rotator cuff tendonitis
- Ligament sprains
- Fractures
- Tendon injuries
- Cartilage defects
- COPD
- Kidney failure
- Stroke
- Multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS)
- Dementia
- Erectile dysfunction
- Heart failure
- Diabetes
- Diabetic neuropathy
MSCs possess immunosuppressive properties, reducing the likelihood of immune rejection compared to other foreign cells. Umbilical cord tissue-derived MSCs (UC-MSCs) are particularly immune-privileged, meaning they are universally accepted by the recipient’s body with virtually no risk of rejection. This is because UC-MSCs are essentially “new” and haven’t been “claimed” by a specific immune system. Unlike organ transplantation, UC-MSC therapy doesn’t require blood products or HLA matching.
Regenerative medicine procedures are generally not covered by insurance. While some surgical applications may have billing codes, most treatments are considered out-of-pocket expenses.
The price range for regenerative medicine injections is broad, typically between $1,500 and $7,500.
Our protocol is designed to significantly reduce chronic low-grade inflammation over an extended period. Stem cells possess a unique ability to target areas of inflammation in the body. Research indicates that they can regenerate damaged or diseased tissues, decrease inflammation, and regulate the immune system—contributing to improved health and overall quality of life.
Studies suggest that mesenchymal stem cells (MSCs) may have a positive impact on various conditions, including:
- ALS
- Alzheimer’s disease
- Autoimmune disorders
- COPD and other degenerative/inflammatory lung diseases
- COVID-19 (acute and long-haul)
- Chronic inflammation
- Crohn’s disease
- Type 1 diabetes
- Heart failure and heart disease
- Kidney disease
- Liver disease
- Lupus
- Lyme disease
- Multiple sclerosis
- Degenerative neurological conditions
- Neuropathy
- Parkinson’s disease
- Reflex Sympathetic Dystrophy (RSD) / Complex Regional Pain Syndrome (CRPS)
- Rheumatoid arthritis
- Spinal cord injuries
- Stroke (ischemic and hemiplegic)
- Traumatic brain injury (TBI)
Our protocol aims for long-term stabilization of the condition with a single treatment. Follow-up treatments are not required. While some patients choose to return for additional treatments, typically seeking further improvement, generally one treatment is sufficient for most degenerative conditions.
Patients generally report minimal discomfort during treatment, often describing the experience as painless.
While individual responses vary, many study participants report noticeable improvements within 1-3 months after treatment. These improvements are evidenced by reduced systemic inflammation and increased vitality, as measured by follow-up questionnaires. Some patients report improvements in symptoms and quality of life even sooner, within the first few days post-treatment.
Umbilical cord-derived mesenchymal stem cells (UC-MSCs) are particularly effective for systemic delivery via intravenous infusion. Their optimal size (17-19 micrometers) allows for efficient passage through the circulatory system, including the lungs. Although a portion of MSCs may initially be trapped in the lungs (a phenomenon known as the pulmonary first-pass effect), this does not negate their therapeutic benefits. MSCs possess a remarkable homing ability – they can actively migrate to damaged tissues. Even while temporarily in the lungs, MSCs exert beneficial paracrine effects: they secrete growth factors and other molecules that reduce inflammation and stimulate tissue repair. Advances in research are continually enhancing the delivery and efficacy of MSCs for regenerative therapies.
Potential of Stem Cells in Anti-Aging and Rejuvenation
Current research suggests that stem cell therapies may have the potential to mitigate some effects of aging and improve overall healthspan. Stem cells, particularly mesenchymal stem cells (MSCs), possess properties that could contribute to this, including their ability to:
- Repair damaged tissues: Stem cells can differentiate into various cell types, potentially replacing aged or damaged cells.
- Reduce inflammation: Chronic inflammation is a key contributor to age-related decline, and MSCs have anti-inflammatory effects.
- Modulate the immune system: MSCs can help regulate immune function, which often declines with age.
- Homing Capability: Stem cells can migrate to sites of damage or inflammation.
The concept of a “protective shield” created by stem cells and anti-aging genes is a simplified representation of these complex biological processes. While a complete reversal of aging is not currently feasible, studies suggest that stem cell interventions, potentially in combination with therapies targeting aging-related genes, could contribute to a healthier and potentially longer lifespan. It’s crucial to understand that this is an area of ongoing research, and many claims about “anti-aging” stem cell treatments are not yet supported by robust clinical evidence.
Potential Benefits of Stem Cell Therapy (Observed and Reported):
Some reported benefits of stem cell therapies, particularly in the context of age-related decline, include:
- Increased energy and vitality
- Improved physical capacity and endurance
- Improved hair quality and thickness
- Enhanced libido
- Pain reduction
- Increased strength, balance, and overall mobility
- Enhanced immune function
- Overall improvement in quality of life
- Reduced inflammatory markers
Mesenchymal stem cells (MSCs) are not a cause of graft-versus-host disease (GVHD); in fact, they are being investigated as a potential treatment for this condition. GVHD is a serious complication that can occur after allogeneic hematopoietic stem cell transplantation (typically bone marrow or cord blood transplants), where the donor’s immune cells (T-cells) attack the recipient’s tissues.
MSCs possess immunomodulatory properties that make them promising candidates for GVHD therapy. They achieve this through several mechanisms, including:
- Secretion of bioactive molecules: MSCs release proteins, peptides, and hormones that can suppress the immune response.
- Mitochondrial transfer: MSCs can transfer mitochondria (the energy-producing components of cells) to damaged cells, potentially aiding in tissue repair.
- Exosome and microvesicle release: MSCs release small vesicles containing RNA and other molecules that can influence the behavior of recipient cells, including immune cells.
While many studies suggest that MSC therapy can be beneficial for both acute and chronic GVHD, more extensive, large-scale, randomized controlled trials are needed to definitively confirm these findings and establish optimal treatment protocols.
It is important to clarify a distinction: although MSCs can modulate the activity of immune cells like T-lymphocytes and B-lymphocytes (reducing their proliferation and secretion of inflammatory factors), they are not broadly immunosuppressive in the same way as traditional immunosuppressant drugs. They have targeted immunomodulatory effects, rather than causing widespread immune suppression. This targeted effect is one reason they are promising for treating GVHD.
Follow-up vitality questionnaires indicate that approximately 85% of patients report sustained improvement in their condition within three months of treatment.